研究揭示深海無脊椎動(dòng)物中磷脂對(duì)壓力的同彎曲適應(yīng)
2024.07.01美國加州大學(xué)舊金山分校Itay Budin等研究人員合作揭示深海無脊椎動(dòng)物中磷脂對(duì)壓力的同彎曲適應(yīng)應(yīng)。相關(guān)論文于2024年6月28日發(fā)表在《科學(xué)》雜志上。
研究人員描述了梳水母（櫛水母）的一種壓力適應(yīng)模式，這種模式也限制了這些動(dòng)物的深度范圍。對(duì)深海櫛水母脂質(zhì)的結(jié)構(gòu)分析表明，它們?cè)趬毫ο滦纬闪朔请p層相，而這種相通常并不穩(wěn)定。脂質(zhì)組學(xué)和全原子模擬發(fā)現(xiàn)，磷脂具有很強(qiáng)的負(fù)自發(fā)曲率，包括縮醛磷脂，這是導(dǎo)致這種相行為的深海適應(yīng)膜的標(biāo)志。
在大腸桿菌中，合成磷脂可提高耐壓性，而低曲率磷脂的效果則相反。對(duì)櫛水母組織的成像表明，深海動(dòng)物在減壓時(shí)的解體可能是由其磷脂膜的相變驅(qū)動(dòng)的。
據(jù)悉，靜水壓力隨著海洋深度的增加而增加，但人們對(duì)生物耐壓的分子基礎(chǔ)知之甚少。
附：英文原文
Title: Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates
Author: Jacob R. Winnikoff, Daniel Milshteyn, Sasiri J. Vargas-Urbano, Miguel A. Pedraza-Joya, Aaron M. Armando, Oswald Quehenberger, Alexander Sodt, Richard E. Gillilan, Edward A. Dennis, Edward Lyman, Steven H. D. Haddock, Itay Budin
Issue&Volume: 2024-06-28
Abstract: Hydrostatic pressure increases with depth in the ocean, but little is known about the molecular bases of biological pressure tolerance. We describe a mode of pressure adaptation in comb jellies (ctenophores) that also constrains these animals’ depth range. Structural analysis of deep-sea ctenophore lipids shows that they form a nonbilayer phase at pressures under which the phase is not typically stable. Lipidomics and all-atom simulations identified phospholipids with strong negative spontaneous curvature, including plasmalogens, as a hallmark of deep-adapted membranes that causes this phase behavior. Synthesis of plasmalogens enhanced pressure tolerance in Escherichia coli, whereas low-curvature lipids had the opposite effect. Imaging of ctenophore tissues indicated that the disintegration of deep-sea animals when decompressed could be driven by a phase transition in their phospholipid membranes.
DOI: adm7607
Source: https://www.science.org/doi/10.1126/science.adm7607
期刊信息
Science：《科學(xué)》，創(chuàng)刊于1880年。隸屬于美國科學(xué)促進(jìn)會(huì)，IF：63.714
官方網(wǎng)址：https://www.sciencemag.org
